| 2009 | Hold the Line | Major Lazer feat. Mr. Lex & Santigold | | 6 |
| 2009 | Keep It Goin’ Louder | Major Lazer feat. Nina Sky & Ricky Blaze | | 7 |
| 2009 | Pon de Floor | Major Lazer feat. Vybz Kartel & Afrojack | | 2 |
| 2011 | German Elefant Killer | Major Lazer | | 1 |
| 2011 | Original Don | Major Lazer feat. The Partysquad | | 3 |
| 2011 | Who Run de Floor on Halloween | AnimalStatuS vs. Major Lazer | | 1 |
| 2012 | Get Free | Major Lazer feat. Amber of Dirty Projectors | | 8 |
| 2012 | Jah No Partial | Major Lazer feat. Flux Pavilion | | 5 |
| 2013 | Watch Out for This (Bumaye) | Major Lazer feat. Busy Signal, The Flexican & FS Green | | 1 |
| 2014 | Aerosol Can | Major Lazer feat. Pharrell Williams | | 2 |
| 2014 | We Make It Bounce | Dillon Francis feat. Major Lazer & Stylo G | | 1 |
| 2014 | All My Love | Major Lazer feat. Ariana Grande | 5 | 1 |
| 2014 | Turn Around | Zeds Dead x Major Lazer ft. Elephant Man | | 1 |
| 2015 | Lean On | Major Lazer x DJ Snake feat. MØ | 2.5 | 3 |
| 2015 | Roll the Bass | Major Lazer | | 1 |
| 2015 | Night Riders | Major Lazer feat. Travi$ Scott, 2 Chainz, Pusha T & Mad Cobra | | 1 |
| 2015 | Too Original | Major Lazer feat. Elliphant & Jovi Rockwell | | 1 |
| 2015 | Lost | Major Lazer feat. MØ | | 1 |
| 2015 | One Wine | Machel Montano & Sean Paul feat. Major Lazer | | 1 |
| 2016 | Number One | Major Lazer & Grandtheft | | 1 |
| 2016 | The Sound | Autoérotique x Major Lazer | | 1 |
| 2016 | Cold Water | Major Lazer feat. Justin Bieber & MØ | 5 | 5 |
| 2016 | Believer | Major Lazer & Showtek | | 3 |
| 2016 | My Number | Major Lazer & Bad Royale | | 1 |
| 2016 | Who Am I? | Katy B, Major Lazer & Craig David | | 1 |
| 2017 | Run Up | Major Lazer feat. PARTYNEXTDOOR & Nicki Minaj | | 1 |
| 2017 | Tip Pon It | Sean Paul & Major Lazer | | 1 |
| 2017 | Где твоя любовь? | Скриптонит feat. Major Lazer | | 2 |
| 2018 | Miss You | Cashmere Cat, Major Lazer & Tory Lanez | 5 | 1 |
| 2018 | Loko | Tropkillaz & Major Lazer feat. MC Kevinho & Busy Signal | | 2 |
| 2018 | Let Me Live | Rudimental & Major Lazer ft. Anne‐Marie & Mr. Eazi | | 4 |
| 2018 | Let Me Live (acoustic) | Rudimental & Major Lazer ft. Anne‐Marie & Mr. Eazi | | 2 |
| 2018 | All My Life | Major Lazer feat. Burna Boy | | 1 |
| 2018 | Tied Up | Major Lazer feat. Mr Eazi, RAYE and Jake Gosling | | 1 |
| 2018 | Blow That Smoke | Major Lazer feat. Tove Lo | | 1 |
| 2019 | Can't Take It from Me | Major Lazer feat. Skip Marley | | 1 |
| 2019 | Make It Hot | Major Lazer & Anitta | | 1 |
| 2019 | Qué calor | Major Lazer feat. J Balvin & El Alfa | | 3 |
| 2019 | Evapora | IZA, Ciara & Major Lazer | | 1 |
| 2020 | Rave de favela | MC Lan x Major Lazer x Anitta feat. BEAM | | 1 |
| 2020 | Lay Your Head on Me | Major Lazer feat. Marcus Mumford | | 2 |
| 2020 | Oh My Gawd | Mr Eazi & Major Lazer feat. Nicki Minaj & K4mo | | 5 |
| 2020 | QueLoQue | Major Lazer feat. Paloma Mami | | 3 |
| 2021 | Pra te machucar | Major Lazer & Ludmilla feat. ÀTTØØXXÁ & Suku Ward | | 3 |
| 2021 | Diplomatico | Major Lazer feat. Guaynaa | | 3 |
| 2021 | Titans | Major Lazer feat. Sia & Labrinth | | 3 |
| 2021 | La mano | Ghetto Kids, Major Lazer & Guaynaa | | 1 |
| 2023 | Number 1 | James Hype & Major Lazer | | 2 |
| 2024 | Jiggy Woogie | Don Diablo, Major Lazer & Baby Lawd | | 1 |
| 2024 | Jiggy Woogie (Extended Mix) | Don Diablo, Major Lazer & Baby Lawd | | 1 |
| 2024 | Nobody Move | Major Lazer & Vybz Kartel | | 1 |
