Helmut Müller-Brühl (28 June 1933 – 2 January 2012) was a German conductor.
Müller-Brühl was a pupil of Hermann Abendroth, the founder of Cologne Chamber Orchestra. In 1958, Müller-Brühl invited this orchestra to be the principal orchestra for concerts given at his family home, Schloss Brühl. In 1964, the orchestra's conductor, Erich Kraak, invited Müller-Brühl to be chief conductor, and Müller-Brühl led the orchestra until 2008. Müller-Brühl also successfully collaborated with Takako Nishizaki on the “Discovery” album of violin concertos by the Chevalier de Saint-Georges. Müller-Brühl died on January 2, 2012 following a long illness. He was 78.