The Fred Frith Guitar Quartet was a United States-based contemporary classical and experimental music guitar quartet comprising Fred Frith, René Lussier, Nick Didkovsky and Mark Stewart. The group was formed in 1989 by Frith and they performed extensively across North America and Europe for the next ten years, including at the 14th Festival International de Musique Actuelle de Victoriaville in Victoriaville, Quebec, Canada in May 1997. They recorded their first album, Ayaya Moses in 1996 and released a live album, Upbeat in 1999.
The quartet experimented with guitar music, composing and performing their own material, improvising, and re-arranging existing guitar pieces by other composers. Their music varied from "tuneful and pretty, to noisy, aggressive and quite challenging."